The GRRR-OH was created in 2003 at the St-Louis hospital with the primary objective to assess optimal management strategies for cancer patients with acute respiratory failure. The steering committee at that time included physicians trained to pulmonary care and board certified in critical care. Then critical care specialists with different backgrounds joined the board to share their willingness to improve critical care management of immunocompromised patients. Teams involved in the GRRR-OH belong to university-affiliated hospitals, community hospitals, as well as cancer centers. Studies led by the GRRR-OH are funded by the French ministry of health, through the hospital clinical research program (PHRC). To date, eleven projects have been funded, including five ongoing trials that are currently recruiting in the 32 centers belonging to the GRRR-OH. Besides randomized controlled trials, case studies and cohorts are constituted to better describe a given disease or fine tune a specific management. The GRRR-OH also handles a database that included up to 10,000 patients on December 2019

The main GRRR-OH objectives are the ten following

  • To conduct clinical and translational research to improve care and management of critically ill immunocompromised patients
  • To conduct trials enabling to validate appropriate interventions to improve care and management of critically ill immunocompromised patients. Even though the primary GRRR-OH topic is acute respiratory failure, worldwide experts in severe infections, antibiotic stewardship, acute kidney injury or transfusion policies are conducting highly impactful trials.
  • To transfer knowledge about acute respiratory failure and management of critically ill immunocompromised patients. Hence, three meetings are set up every year: one in March is the international meeting of the Nine-i that involves 16 countries; one meeting in June that is at a national level; and one meeting in November that is held outside Saint-Louis, in a stronghold city of the GRRR-OH.
  • To conduct a university diploma (Paris university) about the care of critically ill immunocompromised patients (REAMID, 100 hours, 85 delegates in 2019/2020)
  • To conduct an international training course in ICU hematology in January every year (blood diseases in the ICU, 50 hours)
  • To develop an international collaboration with the Nine-i (created in 2015)
  • To contribute international guidelines for the management of immunocompromised patients
  • To promote research about immunocompromised through the Antoine Rabbat research grant
  • To develop tele-expertise and guide management of critically ill immunocompromised patients from less experienced centers
  • To promote nursing expertise and research about critically ill immunocompromised patient